Premium Necoline Powder - China GMP Certified Quality

• Customization: Available
• Varieties: Parasite Disease Prevention Medicine
• Component: Botany
• Type: The First Class
• Pharmacodynamic Influential Factors: Animal Species
• Storage Method: Moisture Proof
• Veterinary Reg. No.: 3004
• Transport Package: in Plastic Bags
• Specification: 500g, 1KG
• Trademark: Huabang
• Origin: China
• HS Code: 3004
• Production Capacity: 50000 PCS Per Week

Product Description

Neocoline WSP Powder for Poultry use

Main Composition:
Neomycin Sudphate B.P - 70g
Colistin Sulphate B.P - 4g
Chlorteteracyeline HCLB.P - 80g

Description:
This product is off-white to yellowish powder.

Pharmacologic action:
Neomycin belongs to the class of aminoglycoside antimicrobials, with an antimicrobial spectrum similar to that of kanamycin. It has strong antibacterial effect on most gram-negative bacilli, such as Escherichia coli, Proteus, Salmonella and Pasteurella multocida, etc. It is also sensitive to Staphylococcus aureus. Pseudomonas aeruginosa, Gram-positive bacteria (except Staphylococcus aureus), rickettsiae, anaerobes and fungi are resistant to the product.

Neomycin is rarely absorbed when taken internally and applied topically; only 3% of the total amount is excreted in the urine after internal administration, and most of it is excreted unchanged in the feces. Absorption may be increased by inflammation of the intestinal mucosa or by the presence of ulcers. Injectable administration is rapidly absorbed, and the in vivo process is similar to that of kanamycin.

Neomycin is overwhelmingly used as a topical preparation, such as Neosporin. It can also be given orally, where it is usually combined with other antibiotics. Neomycin is not absorbed from the gastrointestinal tract and has been used as a preventive measure for hepatic encephalopathy and hypercholesterolemia. By killing bacteria in the intestinal tract, it keeps ammonia levels low and prevents hepatic encephalopathy, especially prior to GI surgery. It has also been used to treat small intestinal bacterial overgrowth. It is not given intravenously, as neomycin is extremely nephrotoxic (causes kidney damage), especially compared to other aminoglycosides. The exception is when neomycin is included, in very small quantities, as a preservative in some vaccines - typically 0.025 mg per dose.

Drug interactions
(1) Combined with macrolide antibiotics for the treatment of mastitis due to gram-positive bacteria.

(2) Internal use may affect the absorption of digitalis drugs, vitamin A or vitamin B12.

(3) Combination with penicillins or cephalosporins has a synergistic effect.

(4) The antibacterial effect of this product is enhanced in alkaline environment, combined with alkaline drugs (such as sodium bicarbonate, aminophylline, etc.) can enhance the antibacterial efficacy, but the toxicity is also increased accordingly. When the pH exceeds 8.4, the antibacterial effect is weakened.

(5) Ca2+, Mg2+, Na+, NH4+ and K+ and other cations can inhibit the antibacterial activity of the product.

(6) Combining with cephalosporins, dextrose, strong diuretics (e.g. furosemide, etc.), erythromycin, etc. can enhance the ototoxicity of the product.

(7) Skeletal muscle relaxants (e.g., succinylcholine chloride, etc.) or drugs with such effects may enhance the neuromuscular blocking effect of this product.

Function and use:
Aminoglycoside antibiotic. Mainly used for the treatment of gastrointestinal infections caused by sensitive gram-negative bacteria.

Usage and dosage:
Calculated based on this product. Mixing: 0.15-0.23g of poultry per 1L of water. Continuous use for 3-5 days.

Adverse reactions:
Neomycin is most toxic to aminoglycosides, but there are few toxic reactions when administered orally or topically.

Precaution:
Chickens that lay eggs for human consumption are not allowed to be used during the laying period.

Withdrawal period: 
Chicken 5 days,turkey 14 days.

Specification:
Neomycin Sudphate B.P - 70g
Colistin Sulphate B.P - 4g
Chlorteteracyeline HCLB.P - 80g

Package: 
500g or1000g/bag, or as reqired

Storage: 
Seal and store in a dry place.

Shelf life:
2 years

Service we can provide:
1. Mixed container, we can mix different items in one container.
2. Quality control, before shipment, free sample for test. After shipment, keep sample for 3 years
3. Prompt shipment with professional documents
4. Packing as your request, with photo before shipment.