COMPOSITION Contains per ml.: Ketoprofen 100mg Solvents ad. 1 ml. PHARMACOLOGY Ketoprofen,2-(phenyl 3-benzoyl) propionic acid is a non-steroidal anti-inflammatory drug belonging to the arylpropionic acid group. The primary mechanism of action for ketoprofen is considered to be inhibition of the cyclooxygenase pathway of arachidonic acid metabolism,leading to decreased production of inflammatory mediators,such as prostaglandins and thromboxanes.This mechanism of action results in its anti-inflammatory,anti-pyretic and analgesic activity.These properties are also attributed to its inhibiting effect on bradykinin and superoxide anions together with its stabilizing action on lysosomal membranes. The anti-inflammatory effect is enhanced by the conversion of the(R)-enantiomer to (S)-enantiomer. It is known that the(S)-enantiomer supports the ant-inflammatory effect of ketoprofen. INDICATIONS Horse: -The alleviation of inflammation and pain associated with musculoskeletal disorders; -The alleviation of visceral pain associated with colic. Cattle: -The supportive treatment of parturient paresis associated with calving; -Reducing the pyrexia and distress associated with bacterial respiratory disease when used in conjunction with antimicrobial therapy as appropriate; -Improving the recovery rate in acute clinical mastitis, including acute endotoxin mastitis, caused by gram negative micro-organisms, in conjunction with antimicrobial therapy; -Reducing oedema of the udder associated with calving; -Reducing pain associated with lameness
Pigs: -Reducing the pyrexia and respiratory rate associated with bacterial or viral respiratory disease when used in conjunction with antimicrobial therapy as appropriate; -The supportive treatment of Mastitis Metritis Agalactia Syndrome in sows, in conjunction with antimicrobial therapy as appropriate. ADMINISTRATION AND DOSAGE Horse: For use in musculoskeletal conditions, the recommended dosage is 2.2 mg ketoprofen/kg i.e. 1 ml/45 kg bodyweight, administered by intravenous injection once daily for up to 3 to 5 days. For use in equine colic, the recommended dosage is 2.2 mg/kg (1 ml/45 kg) bodyweight, given by intravenous injection for immediate effect. A second injection may be given if colic recurs. Cattle: The recommended dose is 3 mg ketoprofen/kg bodyweight, i.e. 1 ml/33 kg bodyweight, administered by intravenous or deep intramuscular injection once daily for up to 3 days. Pigs: The recommended dose is 3 mg ketoprofen/kg bodyweight, i.e. 1 ml/33 kg bodyweight, administered once by deep intramuscular injection. WITHDRAWAL TIME Cattle: Meat and offal: 2 days Milk: Zero hours Horses: Meat and offal:1 day Milk: Not authorized for use in mares producing milk for human consumption Pig: Meat and offal:3 days. Shelf life: 3 years STORAGE: Protect from light and store in a cool dry place and below 30ºC.
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